Download Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is key to homeostasis within the breathing tract. against this, whilst irregular, mucus contributes considerably to the pathophysiology of a couple of serious bronchial ailments, together with bronchial asthma, power bronchitis and cystic fibrosis. This quantity presents huge ranging and in-depth insurance of the clinical and scientific elements of airway mucus. It commences with introductory chapters which deal with the biochemical and molecular organic foundation of airway mucus and maintains with complete assurance of some of the physiological and rheological features of breathing secretions. The medical elements of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory ailments of the airway. the quantity concludes with a dialogue of the healing facets of the subject, either by way of the prospective ways to the remedy of mucus hypersecretion and the interplay of those medicines with airway mucus. Written via best specialists within the box, every one contribution presents a entire overview of its specific topic. Reflecting the most recent advances during this vital quarter of breathing study, this quantity could be of serious curiosity to scientists and clinicians operating within the box of airway secretions and comparable areas.

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However, significant amounts of the MUC2 mucin were not found in the thick gel obstructing the airway of an individual who died in status asthmaticus [6] or in sputum from chronic bronchitic patients [46]. 3. Size In cystic fibrosis, mucin preparations contain a significant proportion of small species, and since the newly synthesised mucins are not inherently smaller [18], the decrease in size has been taken as evidence of proteolytic degradation [5]. In contrast, the majority (85% of the total weight) of the mucins isolated from a patient with asthma were much larger than those observed in the normal airways, leading to the speculation that these glycoproteins are abnormal in size and may lack some processing steps in 32 D.

1. Thornton et aI. the former two amino acids are the sites of O-glycan attachment via the linkage sugar N-acetylgalactosamine. The cysteine residues appear to be confined to the "naked" domains, which are likely to be folded and stabilised by disulphide bonds. Electron microscopy of mucins before and after reduction [4, 5] together with a wealth of physical data [4-7] has led us to propose that intact mucins are polymers formed from disulphide bond-linked monomers (subunits) joined end to end in a linear array.

Acknowledgements The authors wish to thank Mrs Marj Howard, Ms Annika Book and Mr Anders Hansson for their expert technical assistance. Work supported by grants from the Wellcome Trust, the Cystic Fibrosis Research Trust, the British Lung Foundation, the Swedish Medical Research Council (grant nos. 7902, 9823, 9711), the Medical Faculty of Lund, the Swedish National Association Against Heart and Chest Diseases, Centrala fOrsoksdjursnamnden (CFN), the Smokeless Tobacco Research Council Inc. (USA), Greta and Johan Kocks Stiftelse, Stiftelsen Lars Hiertas Minne, Tore Nilssons Fund for Medical Research, Stiftelsen Riksforbundet Cystisk Fibros and Alfred Osterlunds Stiftelse.

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