Download Antihypertensive Drugs Today by G. L. Wollam, R. W. Gifford Jr., R. C. Tarazi (auth.), R. N. PDF

By G. L. Wollam, R. W. Gifford Jr., R. C. Tarazi (auth.), R. N. Brogden (eds.)

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1977). , 1977). Following acute and chronic administration, prazosin lowers arterial pressure by decreasing peripheral vascular resistance and cardiac output is usually unchanged or slightly increased (Lund-Johansen, 1975). Because of the relaxant effect on venous capacitance vessels, prazosin may cause a reduction in venous return to the heart. , 1978). , 1977). , 1977). 2 Pharmacokinetics The pharmacokinetics of prazosin are not well understood. , 1976); however, its therapeutic action does not appear to be closely related with plasma levels (Collins and Pek, 1975).

4 Side Effects There are a number of potentially serious side effects which are occasionally associated with ~-adrenoceptor blocking agents. Patients with a history of bronchial asthma or obstructive airway disease should probably not receive ~-blockers because of the possibility of aggravating bronchospasm. Presumably, the 'cardioselective' agents (because of their lesser affinity for the ~2 receptors) and the agents with 'intrinsic sympathomimetic activity' (because of their partial agonistic effect) should have less tendency to produce bronchospasm.

Reserpine rapidly crosses the blood-brain barrier and depletes brain tissue of serotonin and dopamine as well as noradrenaline (Vogt, 1959). This latter action probably accounts for the sedation and depression which is frequently associated with reserpine. However, central sympathetic outflow is not significantly altered by reserpine (Iggo and Vogt, 1960) and the effect on the central nervous system is thought to be less important than its peripheral effect in regard to its antihypertensive potency (Nickerson and Collier, 1975), although this remains controversial.

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