Download Basic and Applied Bone Biology by David B. Burr, Matthew R. Allen PDF

By David B. Burr, Matthew R. Allen

This booklet presents an summary of skeletal biology from the molecular point to the organ point, together with mobile keep watch over, interplay and reaction; adaptive responses to numerous exterior stimuli; the interplay of the skeletal approach with different metabolic strategies within the physique; and the impression of varied illness strategies at the skeleton. The book also comprises chapters that tackle how the skeleton could be evaluated by utilizing a number of imaging applied sciences, biomechanical checking out, histomorphometric research, and using genetically transformed animal models.

  • Presents an in-depth evaluate of skeletal biology from the molecular to the organ level
  • Offers "refresher" point content material for clinicians or researchers outdoor their components of expertise
  • Boasts editors and plenty of bankruptcy authors from Indiana and Purdue Universities, of the broadest and inner most courses in skeletal biology within the US; different bankruptcy authors comprise clinician scientists from pharmaceutical businesses that observe the fundamentals of bone biology

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Additional resources for Basic and Applied Bone Biology

Example text

7). The entire process can be divided into steps comprising proliferation, extracellular matrix development and maturation, mineralization, and apoptosis. Each stage is characterized by activation of specific transcription factors and genes leading to a succession of osteoblast phenotypic markers. Thus, transcription factors of the helix-loop-helix family [DNA-binding protein inhibitor ID (Id), twist-related protein 1 (Twist), and twist-related protein 2 (Dermo-1)] are expressed in proliferating osteoblast progenitors and are responsible for maintaining the osteoprogenitor population by inhibiting the expression of genes that characterize the mature osteoblast phenotype.

Furthermore, inactivating mutations of the human CTSK gene (encoding cathepsin K) result in pyknodysostosis, a disorder characterized by increased bone mass, dwarfism, and facial dysmorphism. Thus, polarization, acidification, and enzymatic dissolution of bone are all critical for osteoclast function. Once bone dissolution occurs, the products of resorption can be internalized by osteoclasts and travel inside vesicles to lysosomes (Fig. 3), where they are degraded or are transported to the basolateral surface and discharged to the extracellular milieu.

Thus, the BRC provides a supportive environment for the differentiation of osteoclast and osteoblast progenitors, and is under the influence of hormonal and mechanical stimuli, thus permitting tight regulation of bone remodeling. OSTEOCYTES Bone Lining Cells After completion of their bone matrix-synthetizing function, some osteoblasts become flattened and cover the inactive bone surface as bone lining cells. Lining cells may recover the ability to produce matrix in response to PTH, a mechanism that may contribute to the rapid increase in bone formation observed upon daily administration of the hormone.

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