By Thomas Seyfried
The booklet addresses controversies relating to the origins of melanoma and offers ideas to melanoma administration and prevention. It expands upon Otto Warburg's recognized concept that every one melanoma is a disorder of power metabolism. in spite of the fact that, Warburg didn't hyperlink his concept to the "hallmarks of melanoma" and hence his idea used to be discredited. This ebook goals to provide evidence, via case studies, that melanoma is essentially a metabolic ailment requring metabolic strategies for its administration and prevention. help for this place is derived from severe review of present melanoma theories. mind melanoma case reports are provided as an explanation of precept for metabolic strategies to affliction administration, yet similarities are interested in different kinds of melanoma, together with breast and colon, because of the same cellular mutations that they reveal.
Chapter 1 photographs of melanoma (pages 1–14):
Chapter 2 Confusion Surrounds the foundation of melanoma (pages 15–29):
Chapter three melanoma versions (pages 31–46):
Chapter four Energetics of ordinary Cells and melanoma Cells (pages 47–72):
Chapter five respiration disorder in melanoma Cells (pages 73–105):
Chapter 6 The Warburg Dispute (pages 107–117):
Chapter 7 Is breathing basic in melanoma Cells? (pages 119–132):
Chapter eight Is Mitochondrial Glutamine Fermentation a lacking hyperlink within the Metabolic thought of melanoma? (pages 133–144):
Chapter nine Genes, breathing, Viruses, and melanoma (pages 145–176):
Chapter 10 respiration Insufficiency, the Retrograde reaction, and the starting place of melanoma (pages 177–194):
Chapter eleven Mitochondria: the last word Tumor Suppressor (pages 195–205):
Chapter 12 Abnormalities in development keep watch over, Telomerase task, Apoptosis, and Angiogenesis associated with Mitochondrial disorder (pages 207–213):
Chapter thirteen Metastasis (pages 215–252):
Chapter 14 Mitochondrial breathing disorder and the Extrachromosomal starting place of melanoma (pages 253–259):
Chapter 15 not anything in melanoma Biology is sensible other than within the gentle of Evolution (pages 261–275):
Chapter sixteen melanoma therapy innovations (pages 277–289):
Chapter 17 Metabolic administration of melanoma (pages 291–354):
Chapter 18 sufferer Implementation of Metabolic cures for melanoma administration (pages 355–373):
Chapter 19 melanoma Prevention (pages 375–386):
Chapter 20 Case stories and private reviews in utilizing the Ketogenic nutrition for melanoma administration (pages 387–403):
Chapter 21 Conclusions (pages 405–408):
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Extra resources for Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer
Faguet G. The War on Cancer: an Anatomy of a Failure, a Blueprint for the Future. Dordrecht, The Netherlands: Springer; 2008. 9. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA Cancer J Clin. 2003;53:5–26. 10. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–49. 11. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66. 12. Salk JJ, Fox EJ, Loeb LA.
Tumor cell invasion of surrounding tissues and spread to distant organs is the primary cause of morbidity and mortality in most cancer patients. This phenomenon is referred to as metastasis. The biological process by which normal cells are transformed into malignant cancer cells has been the subject of an enormous research effort in the biomedical sciences for more than a century. Despite this effort, cures or long-term management strategies for metastatic cancers are as challenging today as they were 40 years ago when President Richard M.
Despite this effort, cures or long-term management strategies for metastatic cancers are as challenging today as they were 40 years ago when President Richard M. Nixon declared a war on cancer with the National Cancer Act (1–3). According to the American Cancer Society, 569,490 people died in the United States from cancer in 2010 (4). This comes to about 1500 people each day! Remarkably, the number of deaths in 2002 was 555,500 providing quantitative evidence of no real progress in management over a 8-year period (5).