By Gerhardus de Jong
This monograph bargains the reader an entire evaluate on either rules and purposes of CE-MS. beginning with an introductory bankruptcy on detection in CE, additionally similar and extra really expert thoughts corresponding to electrophoretic and chromatographic preconcentration are mentioned. a distinct emphasis is wear CE-MS interfaces, that are defined intimately. In a separate bankruptcy, realization is paid to sheath-liquid interfacing. The advancements and probabilities of microchip CE-MS also are defined. purposes to all proper parts are mentioned in certain chapters, every one written via specialists within the respective fields.
along with purposes in pharmaceutical research and bioanalysis, contemporary implementations in meals technological know-how, forensic research, research of intact proteins, metabolomics and proteomics are highlighted. MS is a wonderfully acceptable detection process for CE, as effective separation is coupled to delicate and choice detection. furthermore, MS gives you constitution info at the separated compounds. CE-MS has now been built right into a powerful hyphenated method complementary to LC-MS. This monograph is an targeted resource of data for everybody facing and drawn to CE-MS
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Additional info for Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications
Edited by Gerhardus de Jong. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2016 by Wiley-VCH Verlag GmbH & Co. KGaA. 42 3 Sheath Liquids in CE-MS: Role, Parameters, and Optimization and discussions of interface design and development are not the main aim of this chapter, but comprehensive information on this topic can be found in Chapter 2 of this book as well as from a series of review papers [6–11]. In this chapter, primarily SL-related chemical and physical parameters are discussed, which include SL composition as well as SL ﬂow rate and closely related issues such as the nebulizer pressure.
Another advantage is the fact that SL-based interfaces for CE-MS are easy to use, at least compared to most sheathless designs. Over the years, a variety of diﬀerent interface designs have been reported, but the use of most of them remained restricted to a few publications, mostly by the developing group . Anyhow, it still took several years before the ﬁrst (almost) “plug-and-play” interfaces for CE-MS arrived as “early” sheath-ﬂow interfaces still required substantial operational skills. For a long time, the sheath-ﬂow interface was the only interface for CE-MS available commercially; only recently, a novel sheathless design from Moini  was introduced to the market by AB-SCIEX.
A, 1267, 162–169. , and Li, L. (2015) Relative quantiﬁcation of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS. Analyst, 140, 467–475. , and Hankemeier, T. (2014) Capillary electrophoresis–mass spectrometry using a ﬂow-through microvial interface for cationic metabolome analysis. Electrophoresis, 35, 1308–1314. J. (2015) High speed capillary zone electrophoresis–mass spectrometry via an electrokinetically pumped sheath ﬂow interface for rapid analysis of amino acids and a protein digest.