Download Clinical Application of Radiolabelled Platelets by M. C. Thakur (auth.), Ch. Kessler, M. R. Hardeman, H. PDF

By M. C. Thakur (auth.), Ch. Kessler, M. R. Hardeman, H. Henningsen, J.-N. Petrovici (eds.)

AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) have been the 1st to post a paper about the in vivo thrombus detection with 111- In-labelled platelets. earlier makes an attempt at scintigraphic thrombus localisation have been disappointing a result of unspecific binding of many of the isotopes used, in addition to the negative labelling potency or an inadequate low gamma-emitting estate. due to its actual features (2.8 days half-life, ninety four% gamma emission) 111 Indium became out to be the simplest isotope for platelet kinetic reports in addition to for the size of platelet incorporation through Thrombi for use up formerly. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets with no changing the functionality or the lifestyles span of the platelets. This virtue has permit to a rise within the medical purposes of 1211-In labelled platelets. this day, radiolabelled platelets are used for thrombus detection in numerous diversified clinical components resembling cardiology, nephrology. angiology or neurology. even supposing many scientists and health center medical professionals now often use radiolabelled platelet as a diagnostic instrument, there's as but no longer a standardized labelling process. as well as this, there are neither standardized snapshot techniques for different scientific functions nor an contract approximately specificity and sensitivity of the tactic. In 1983, a symposium on Radiolabelled mobile Blood components used to be equipped through M.Thakur, M.R.Hardeman and M.D.

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Hirsch (1983) assumes that platelets with a lot of platelets antibodies are phagocytosed by liver 55 macrophages and platelets with a few antibodies by those of the spleen. It would be interesting to compare organ uptake with titrated platelet antibodies. In our investigation this comparison was not included. In 2 patients with recurrent thrombocytopenia after splenectomy, accessory spleen was found. The one hour uptake in the splenic tissue was 2 and 5% respectively, and increased to 12% in the one patient (after 24 hrs) and to 22% in the other (after 48 hrs).

I. is comparable to Inlll-oxine platelet studies (4) and allows to suppose a high Tc-99m-stability in the labelled platelets. The stability of this label and the reproducability of our results still has to be proven in future patient studies. So Tc-99m-HMPAO seems to be a promising platelet labelling compound for clinical studies in imaging thrombosis, although diagnostic problems are present in the abdomen; of course platelet survival studies are not possible due to the short physical half-life of Tc-99m.

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