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By Gladys M. Cox (Auth.)

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He suggests that it interferes with the respiration of the 46 CLINICAL CONTRACEPTION sperms. ). Quinine has probably been more widely used for contra­ ceptive purposes during the past fifty years than any other drugs. Quinine and the allied alkaloids are used in douches, ointments, jeUies, tablets, suppositories, medicated oUs and in powder form. , and the urea hydrochloride is only slightly more spermicidal. The relative clinical success of cocoa-butter suppositories containing quinine is probably due largely to the mechanical barrier formed b y the vehicle, and, in the case of Rendell's pessaries, to the acidity.

Quinine hydrochloride. Potassium oxyquinoline sulphonate. Potassium cyanide. Quinine bisulphate. Catechol. Phenol. Grade o. C. 1 per cent. :— Hydroquinone methyl ether. Acetaldehyde. Chloral hydrate. Resorcinol. Grade — i. C. 2 per cent. :— Pyrogallol. Potassium capronate. Orthophenylene diamine. Ungraded. These fail to immobilise at 2 per cent. :— Ammonium chloride. Zinc sulphocarbolate. Potassium butyrate. Sodium citrate. Hexamine. Sodium tartrate. Magnesium sulphate. Borax. Ethyl alcohol.

Prensols (hexyhesorcinol). Large and small sizes. Prophycols (lactic acid, mercury). Vimule (quinine). W y e t h (quinine, boric acid). Gum Tragacanth and Glycerine. Docker's Contraps (quinine, lactic acid, magnesium sulphate). —These have the advantage of a watersoluble vehicle which facihtates the release of the chemicals. The chemicals are conveyed in a base of combinations of glycerine, glycerite of starch, gums, agar-agar, etc. T h e y act independently of vaginal moisture and of temperature.

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