By Marc A. Fritz MD, Leon Speroff MD
Proven for greater than thirty years as one of many world's most generally learn gynecology texts, medical Gynecologic Endocrinology and Infertility is now in its 8th variation. In a transparent, basic sort improved by way of plentiful illustrations, algorithms, and tables, the e-book presents an entire rationalization of the feminine endocrine process and its issues and gives sensible assistance on overview and remedy of woman endocrine difficulties and infertility. significant sections hide reproductive body structure, medical endocrinology, birth control and infertility. This version has a contemporary full-color design.A spouse web site contains the totally searchable textual content, snapshot financial institution and hyperlinks to PubMed references.
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Extra info for Clinical Gynecologic Endocrinology & Infertility, 8th Edition
The molecular diagnosis of genetic disorders requires only a small sample of DNA, obtainable from any cells that are nucleated, such as white blood cells or epithelial cells. Polymerase chain reaction carried out by automatic machinery allows speedy DNA diagnosis with material amplified from a single cell. This is an important advantage in prenatal genetic analysis and in preimplantation sexing and diagnosis. PCR makes it possible to perform DNA diagnosis from a single cell removed from embryos fertilized in vitro.
Thus, a hydatidiform mole has a normal karyotype, but all of its chromosomes are derived from the father. Placental structures are absent in ovarian teratomas, tumors that contain only maternally derived chromosomes. Experiments in nature and animal experiments indicate that the maternal contribution to the genome is more important for embryonic development. In certain autosomal-recessive conditions, the expression, severity, and age of onset are influenced by the gender of the parent providing the mutant gene or chromosome.
It is not far-fetched to envision marriages and pregnancies avoided because of a bad match of genetic predispositions. Society is developing guidelines regarding the use of this information: by individuals, by employers, by health organizations, and by the government. Scientific progress must be matched by public and professional education to appropriately manage this knowledge. S. National Human Genome Research Institute, A vision for the future of genomics research. A blueprint for the genomic era, Nature 422:835, 2003.