By Thomas K. Day
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Additional info for Clinical Immunology of the Dog and Cat, 2nd Edition
This ‘common mucosal system’ may arise through vascular adhesion molecules shared by mucosal sites and allows differentiation of antigen-specific B lymphocytes at more than one mucosal surface. In domestic species this is of great importance because it enables the production of IgA antibodies specific for enteric or respiratory pathogens within the mammary gland and the passive transfer of such antibodies to neonates. 74 ␣2 ␣1 ␣3 ␣1 ␤1 ␣2 ␤2 ␤2m cell membrane cytoplasm class I class II 37 BASIC IMMUNOLOGY 75 → telomere centromere ← class II (D region) DPB DPA DQB DQA class I class III DRB DRA 21-OH C4B 21-OH C4A Bf C2 HSP70 TNF B C A 75 The major histocompatibility complex.
The maternal and paternal sets of genes (a haplotype) are generally inherited as a block without genetic recombination (77). Studies of the DLA system have revealed differences between breeds in the range of DLA alleles and haplotypes expressed. g. GSD), whereas some breeds have restricted diversity or unique alleles. The degree of polymorphism in DLA class II genes is currently in the order of 31 DLA-DQA1 alleles, 90 DLA-DQB1 alleles and 144 DLA-DRB1 alleles. CYTOKINES 76 Expression of MHC products.
G. the endosome). It is within this compartment that ‘antigen processing’ occurs. Crude antigen is converted to constituent peptide fragments, which are subsequently re-expressed on the surface of the APC, nestled within a groove formed by the variable domains of either class I or class II histocompatibility molecules (antigen presentation). A single MHC molecule may bind many different peptides, but each must have specific anchor residues that fit into specific pockets of the antigen binding groove.