Download Clinical Use of Antiviral Drugs by B. E. Juel-Jensen (auth.), Professor Dr. Erik De Clercq PDF

By B. E. Juel-Jensen (auth.), Professor Dr. Erik De Clercq (eds.)

Antiviral chemotherapy has come of age, and, after an preliminary gradual seasoned­ gress, the improvement of latest antiviral brokers has proceeded at a extra fast speed and the views for his or her medical use have elevated significantly. Now, 25 years after the 1st antiviral assay (idoxuridine) was once brought within the sanatorium, it's becoming to commemorate the start of the antivirals' period. In its introductory bankruptcy B.E. Juel-Jensen touches on what might be con­ sidered as 5 of the main basic specifications of an antiviral drug : efficacy, relative non-toxicity, effortless solubility, prepared availability and rea­ sonable rate. absolutely, the antiviral medications that experience to date been utilized in the health facility may nonetheless be more suitable upon as a number of of those 5 crucial calls for are involved. How is all started is narrated via W.H. Prusoff. the 1st antiviral medicinal drugs for use in people have been methisazone and idoxuridine, the previous, that's now of archival curiosity, within the prevention of smallpox, the latter, which used to be licensed for medical use within the usa in 1962, for the topical remedy of herpetic keratitis. when it comes to efficiency, additionally as a result of solubility purposes, idoxuridine has been outmoded via trifluridine within the topical therapy of herpes simplex epithelial keratitis. H.E. Kaufman didn't locate trifluridine or acyclovir ef­ fective within the therapy of deep stromal keratitis or iritis and he reckons that different antiviral medications (i.e. bromovinyldeoxyuridine) wouldn't be effec­ tive either.

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Clinical Use of Antiviral Drugs

Antiviral chemotherapy has come of age, and, after an preliminary gradual professional­ gress, the improvement of recent antiviral brokers has proceeded at a extra fast velocity and the views for his or her scientific use have elevated significantly. Now, 25 years after the 1st antiviral assay (idoxuridine) used to be brought within the sanatorium, it truly is becoming to commemorate the start of the antivirals' period.

Additional resources for Clinical Use of Antiviral Drugs

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Herpes simplex virus (HSV) types 1 and 2. Further complicating the problem of therapy and its evaluation is the type of virus infection. Although most ocular virus infections are caused by HSV type I, type 2 virus has been cultured from the eye. Thus, there is a danger in using therapeutic agents that might be effective against type 1 but not against type 2. Also, we have shown that the shape, extent, and virulence of corneal infections are determined by the specific DNA composition of the strain or isolate of virus (9,10).

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