Download Diabetes and Viruses by Keith Taylor PDF

By Keith Taylor

Diabetes, in all of its kinds, now constitutes a transforming into wellbeing and fitness obstacle, affecting all segments of the world’s inhabitants. there's nice curiosity within the components which impact its etiology and development. between those, a few viruses function prominently. Hindered by way of technological boundaries, examine into this dating has hitherto been scarce. fresh advances, even if, have unfolded the sphere and there's a burgeoning physique of literature at the topic. regrettably, this literature has been diffuse and infrequently tricky to access.

For the 1st time, this booklet compiles the perspectives of a few of the world’s specialists within the box. It addresses questions, starting from how viruses may perhaps smash or adjust the functionality of pancreatic islets; to which viruses are the main most probably culprits; as to whether vaccines or etiologic cures may be used to avoid virus-induced diabetes. Diabetes and Viruses is the 1st finished quantity on a massive and increasing box of analysis that's of curiosity to clinicians, healthcare managers, epidemiologists, veterinarians, and easy scientists.

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Extra resources for Diabetes and Viruses

Example text

The PTPN22 Gene The PTPN22 gene (1p13) encodes a lymphoid protein tyrosine phosphatase (the protein product called LYP) that is expressed in lymphocytes and is acting through binding intracellular kinases. LYP is involved directly in setting thresholds for T-cell receptor signaling (Cloutier and Veillette 1999). The Arg620Trp polymorphism of this gene is associated with type 1 diabetes in many Caucasian populations, and this variant is a common predisposing factor for other autoimmune diseases as well (Bottini et al.

Enteroviral RNA is more common among patients with type 1 diabetes cases than controls either at the diagnosis or during the period before beta-cell autoantibodies appear. As it was discussed above, IFIH1 gene and the downstream signal mechanism may provide a clue about virus-induced disease mechanisms. These findings are consistent with earlier reports on the pathogenesis of encephalomyocarditis virus-induced diabetes in mice, where the genetic factors of the host play a role (Kang and Yoon 1993).

Autoantibodies, originally identified in type 1 diabetes by Bottazzo et al. (1974), has been detected to four major autoantigens, glutamic acid decarboxylase (GAD65) by Lernmark and colleagues, tyrosine phosphatase-like molecule (IA-2) by Notkins and colleagues, insulin autoantibodies (IAA) by Palmer and colleagues, and zinc transporter-8 autoantibodies (ZnT8) by Hutton and colleagues in about 90% of newly diagnosed patients with type 1 diabetes (Baekkeskov et al. 1982, 1990; Leslie et al. 2001).

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