Download Diabetes Research: A Guide for Postgraduates by Bernard Tuch PDF

By Bernard Tuch

Discusses long term problems and remedy techniques for diabetes, studies overseas realized societies and journals, and offers useful perception into examine at the frontline.

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Extra info for Diabetes Research: A Guide for Postgraduates

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16. Endogenous glucose production (left) and glucose uptake (right) measured in the basal state and in response to insulin or the unknown compound (UC). 17. 2-Deoxyglucose uptake in fat, muscle and brain in response to insulin or the unknown compound administered in vivo. 2. 3. animal is killed with an overdose of anaesthetic and various tissues are sampled. This technique relies on the fact that 2-deoxyglucose is trapped in the tissues as 2-deoxyglucose-6 phosphate with the exception of the liver and kidney which contain glucose-6 phosphatase and can dephosphorylate it, allowing it to be transported out of the cell again.

However, to calculate glucose turnover with this method, it was necessary to assume instant mixing of the injected tracer, an inaccurate assumption which led to inaccurate results. In 1954 Searle and co-workers removed the need to assume instant mixing by combining the single injection with a constant infusion of 14C-glucose. This is the method (with some refinements) that is most widely used currently. In a resting, fasting rat (or human) glucose appearance is constant and is due to the release of glucose from the liver and to a lesser extent the kidney.

Practical exercises It is important for any scientist to have a clear understanding of the techniques used in his or her field of research. In this section, some commonly used methods in metabolic research are briefly described in sufficient detail to allow the student to grasp the important principles of the methods. References are provided to allow a more thorough exploration of a particular technique if required. To place these methods in a realistic context, a scientific problem is posed. Y ou are the scientist in charge of a laboratory owned by a pharmaceutical com pany that is searching for new hypoglycaemic drugs.

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