By W.H.B. Wallace, C.J.H. Kelnar, P.-E. Mullis
Carrying on with advances within the administration of formative years malignancies lead to a speedily growing to be variety of youth melanoma survivors. in spite of the fact that, a lot of them event treatment-induced ‘late results’ together with an important variety of endocrine dysfunctions. during this e-book specialists within the box of past due results of adolescence melanoma remedy supply medical perception into pertinent matters reminiscent of the effect of melanoma treatments on progress, puberty and hypothalamic and pituitary functionality, female and male fertility, weight problems, and metabolic and bone difficulties. Multidisciplinary long term follow-up of those sufferers is vital to watch, deal with and forestall morbidity. for this reason this quantity is of significant curiosity to pediatric endocrinologists and oncologists, grownup and reproductive endocrinologists, fundamental care practitioners, nurses and nurse practitioners in addition to others considering making plans and supplying the holistic care which this more and more quite a few and demanding workforce of sufferers calls for.
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Extra info for Endocrinopathy After Childhood Cancer Treatment (Endocrine Development)
Several unresolved issues remain. g. menarche), the overall effect of treatment on total pubertal duration, or the tempo of puberty, remains less well studied. In longitudinal studies, the tempo of puberty was accelerated in some [20, 23, 25] but not all patient groups . With an accelerated tempo, the duration of the pubertal growth spurt is shortened and there is less time to intervene medically to maximize final height. It is also unclear why girls are more susceptible to alterations in pubertal timing following radiotherapy compared with boys.
49 Ocampo-Lim B, Guo W, DeMott-Friberg R, Barkan AL, Jaffe CA: Nocturnal growth hormone (GH) secretion is eliminated by infusion of GHreleasing hormone antagonist. J Clin Endocrinol Metab 1996;81:4396–4399. 50 Wehrenberg WB, Brazeau P, Luben R, Bohlen P, Guillemin R: Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF). Endocrinology. 1982;111:2147–2148. 22 51 Sklar CA, Constine LS: Chronic neuroendocrinological sequelae of radiation therapy.
J Clin Endocrinol Metab 2005;90:5217– 5225. 92 Mohn A, Chiarelli F, Di Marzio A, Impicciatore P, Marsico S, Angrilli F: Thyroid function in children treated for acute lymphoblastic leukemia. J Endocrinol Invest 1997;20:215–219. 93 Lando A, Holm K, Nysom K, Rasmussen AK, Feldt-Rasmussen U, Petersen JH, Muller J: Thyroid function in survivors of childhood acute lymphoblastic leukaemia: the significance of prophylactic cranial irradiation. Clin Endocrinol 2001;55:21–25. 94 Carter EP, Leiper AD, Chessells JM, Hurst A: Thyroid function in children after treatment for acute lymphoblastic leukaemia.