Download Essentials of Apoptosis: A Guide for Basic and Clinical by Brona M. Murphy, Seamus J. Martin (auth.), Xiao-Ming Yin MD, PDF

By Brona M. Murphy, Seamus J. Martin (auth.), Xiao-Ming Yin MD, PhD, Zheng Dong PhD (eds.)

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Extra resources for Essentials of Apoptosis: A Guide for Basic and Clinical Research

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Mol. Cell. 8(3), 705–711. 21. Oltvai, Z. , Milliman, C. , and Korsmeyer, S. J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74(4), 609–619. 22. Hsu, Y. T. and Youle, R. J. (1998) Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J. Biol. Chem. 273(17), 10777–10783. 23. Sedlak, T. , Oltvai, Z. , Boise, L. , Thompson, C. , and Korsmeyer, S. J. (1995) Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

47. , and Tsujimoto, Y. (1999) Bcl--2 famILy proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399(6735), 483–487. 48. , et al. (2000) BAR: an apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Proc. Natl. Acad. Sci. USA 97(6), 2597–2602. 49. Chau, B. , Cheng, E. , Kerr, D. , and Hardwick, J. M. (2000) Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Mol. Cell 6(1), 31–40. 50. Ng, F. , Branton, P.

Majority of the NCI 60 cell-line panel of cancer cells (57). This loss of XAF1 expression in transformed cells has been proposed to contribute to apoptosis suppression by allowing unrestricted IAP activity. Unlike XAF1, the Smac protein resides in the mitochondria of healthy cells, and is released upon apoptotic stress with similar kinetics to cytochrome c. In the process of being released from the mitochondria, the 55 amino acid mitochondrial localization-signal peptide is proteolytically removed (58,59).

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