By Brona M. Murphy, Seamus J. Martin (auth.), Xiao-Ming Yin MD, PhD, Zheng Dong PhD (eds.)
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Extra resources for Essentials of Apoptosis: A Guide for Basic and Clinical Research
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Majority of the NCI 60 cell-line panel of cancer cells (57). This loss of XAF1 expression in transformed cells has been proposed to contribute to apoptosis suppression by allowing unrestricted IAP activity. Unlike XAF1, the Smac protein resides in the mitochondria of healthy cells, and is released upon apoptotic stress with similar kinetics to cytochrome c. In the process of being released from the mitochondria, the 55 amino acid mitochondrial localization-signal peptide is proteolytically removed (58,59).