By T. Yoshikawa, I. Elmadfa
Meals elements are thought of to be serious for human wellbeing and fitness promoting and play a big function within the prevention of life style similar illnesses. one of many significant demanding situations during this context is to figure out the a number of elements linked to the motives of those illnesses, in addition to to enhance a style of detecting adjustments within the preliminary degree and to set up a diagnostic strategy that may be utilized in prevention reviews of nutrition components. This book positive aspects chapters on genomics, proteomics, bioavailability and protection, antioxidants, way of life similar ailments and on chemoprevention and melanoma. easy scientists with a spotlight on meals elements, clinicians making plans a potential preventive examine of nutrition elements in life-style-related ailments, in addition to corporation researchers learning overall healthiness promotional results of foodstuff or nutrients elements will discover a wealth of knowledge during this ebook.
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Meals elements are thought of to be serious for human healthiness promoting and play an enormous function within the prevention of life style similar illnesses. one of many significant demanding situations during this context is to figure out the a number of elements linked to the motives of those ailments, in addition to to improve a style of detecting adjustments within the preliminary level and to set up a diagnostic method that may be utilized in prevention reviews of nutrients elements.
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Extra info for Food Factors for Health Promotion (Forum of Nutrition Vol 61)
The LXR/PXR-dependent stimulation is mediated by SREBP through LXR/PXR-dependent induction of hepatic SREBP1 expression. The SREBP1 promoter has both an LXR response element (LXRE) and a PXR response element . Therefore, the activation of both nuclear receptors induces SREBP1 expression. The effects of LXR and PXR on the accumulation of hepatic triglyceride (TG) are mainly mediated by SREBP1 activity. The induced SREBP1 increases the mRNA levels of FAS via SREBP response elements in promoter regions of the FAS gene .
The β-cryptoxanthine-fed mice showed no significant difference in body and organ weights. However, their fasting blood glucose level decreased. In addition, oral glucose tolerance test demonstrated improvement in insulin resistance after 4 weeks of feeding with β-cryptoxanthine. The number of small adipocytes increased and that of large ones decreased in the adipose tissues of the β-cryptoxanthine-fed mice in comparison with those of control HFD-fed mice. Interestingly, the gene expression of enzymes involved in fatty acid oxidation in the liver was upregulated in the β-cryptoxanthine-fed mice, such that the hepatic TG content of the β-cryptoxanthine-fed mice was lower than that of the control mice.
20 Teboul L, Febbraio M, Gaillard D, Amri EZ, Silverstein R, Grimaldi PA: Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation. Biochem J 2001;360:305–312. 21 Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W: Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology 2008;134:556–567. 22 Cha BS, Ciaraldi TP, Carter L, Nikoulina SE, Mudaliar S, Mukherjee R, Paterniti JR Jr, Henry RR: PPARgamma and RXR agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.