By H. Vanderhaeghe (auth.), Prof. Erik De Clercq (eds.)
The overseas Symposium on Frontiers in Microbiology has been de dicated to Prof. P. De Somer, whom I succeeded presently after his dying on 17 June 1985 as Rector of this now greater than 560-year previous college. while Prof. De Somer grew to become the pinnacle of the college he began to transform it, giving our previous Alma Mater a extra obvious administrative constitution, strengthening its clinical and cultural autonomy, and developing shut hyperlinks with the main prestigious nationwide and international associations. This made De Somer to 1 of the best, if no longer the best, of rectors within the background of Belgian Universities. He used to be a good chief, an ideal organizer, a smart negotiator, and a super orator. In his speeches one instantly sensed his intuitive cognition and witty assessment of the values of existence. He knew completely good how one can convince the unwilling and to disenchant the illusionist. occasionally a visionary himself, he wouldn't pursue his principles except there has been an opportunity of good fortune. As leading edge Prof. P. De Somer used to be in supplying to this college a brand new face, or may still I say facelifting, as foreign is his acceptance because the founder, and, in view that its inception, purely director, of the Rega Institute. outfitted now greater than 30 years in the past, the Rega Institute has re mained one of many world's top facilities in microbiological research.
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Extra resources for Frontiers in Microbiology: From Antibiotics to AIDS
12 is unprecedented. Though structural changes have occurred as the sequences have diverged, the active-site serine DD-peptidase and B-Iactamases form a very large family of enzymes which are characterized by a similar fold of the polypeptide chains. Differences in the catalyzed reactions can, at least in part, be viewed as the expression of the variations seen in the amino acid composition of some of the conserved boxes. As a corollary, these amino acids are targets of choice to be studied by site-directed mutagenesis.
The advantages and disadvantages of ketoconazole have resulted in an 44 intensified drug design program from which itraconazole (R 51 211) was selected for further development. g. a favorable tissue level/plasma level ratio and a long half-life. In addition, itraconazole has a much greater affinity for the fungal cytochrome P-450 than for the mammalian cytochrome P-450, resulting in an improved safety profile. Clinical results now collected for almost 4,000 patients point to the high potential of itraconazole for the treatment of fungal diseases.
Albicans microsomal P-450 isozyme than does the corresponding portion of ketoconazole. -demethylation of lanosterol or 24-methylenedihydrolanosterol, the precursors of ergosterol. 5 x 10- 10 M of itraconazole (19), whereas for ketoconazole 5 x 10- 9 M were needed (18). Itraconazole is also 10 times more active in Pityrosporum ovale (31). fumigatus were studied. At least 100-fold higher concentrations of ketoconazole than of itraconazole were needed to achieve 50 % inhibition of ergosterol synthesis (16).