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By Lutz Birnbaumer, James Darnell, Ronald Evans, Tony Hunter, Anthony R. Means, Vale Wylie, Bert W. O'Malley

Hormones and Signaling specializes in the mechanism of gene law on the mobile point. It additionally covers the best way hormones act to modulate gene legislation and animal improvement. Key good points* comprises info on:* Nuclear receptors, coactivators, and corepressors* Membrane receptors, kinases, and phosphorylation on cascades* Hormonal law of improvement* Calcium channels and neurotransmitters* Chromatin, transcription components, and legislation of gene expression* JAK/STAT pathways* Hormone-regulated improvement and gene "knock-out"

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Mejia, J. , and Bischoff, P. (1993). Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocyts. Immunology 78, 455-460. 68. , Beck, J. , and Luu, B. (1986). Comparative effects of 7 fi-hydroxycholesterol towards murine lymphomas, lymphoblasts and lymphocytes: Selective cytotoxicity and blastogenesis inhibition. Cancer Biochem. Biophys. 9(1), 75-83. 69. Lin, C. , and Morel, D. W. (1995/.

The time course and pattern of fragmentation differed slightly between the steroids. For example, the TUNEL assay, which measures nicked ends of DNA, was more markedly positive after oxysterol treatment than after dex, and oxysterol-treated cells showed evidence of DNA breakage occurring several hours before overt cell death demonstrated by dye exclusion assays. In general, however, both classes of steroids cause DNA lysis characteristic of apoptosis. 16 E. Brad Thompson C. The Glucocorticoicl Pathway to Apoptosis I.

1993). The effects of hydrocortisone on in vitro lymphocyte proliferation and interleukin-2 and -4 production in corticosteroid sensitive and resistant subjects. Eur. J. Clin. Invest. 23(12), 845-850. 54. Snijdewint, F. , Kapsenberg, M. , Wauben-Penris, P. , and Bos, J. D. (1995). Corticosteroids class-dependently inhibit in vitro TH1- and TH2-type cytokine production. Immunopharmacology 29(2), 93-101. 55. , and Okudaira, H. (1995). IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A.

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