Download Hormones, Intrauterine Health and Programming by Jonathan R Seckl, Yves Christen PDF

By Jonathan R Seckl, Yves Christen

The authors handle particularly the function of hormones and their hyperlinks with different maternal environmental mediators in developmental programming. The an important nature of the placenta as an interface and aim among maternal and foetal environments is addressed. Emphasis is made at the rising technological know-how of epigenetics as a possible reason behind how environmental occasions that happen in the course of short home windows of improvement may perhaps exert results that effect upon somatic cells via many rounds of mitosis for far of the lifestyles span of the following organism.

Show description

Read or Download Hormones, Intrauterine Health and Programming PDF

Similar endocrinology books

Food Factors for Health Promotion (Forum of Nutrition Vol 61)

Meals elements are thought of to be severe for human healthiness promoting and play a tremendous function within the prevention of lifestyle similar illnesses. one of many significant demanding situations during this context is to figure out the a number of components linked to the motives of those illnesses, in addition to to strengthen a style of detecting adjustments within the preliminary degree and to set up a diagnostic process that may be utilized in prevention reviews of nutrition elements.

The Parathyroid Glands: Imaging and Surgery

This e-book is predicated at the authors’ broad functional adventure within the use of contemporary radiological the way to diagnose parathyroid ailments and the appliance of complicated surgical concepts. specified cognizance is dedicated to the embryological historical past to stress the importance of diagnostic and surgical peculiarities.

Klinische Endokrinologie für Frauenärzte

Durch eine grundlegende und in depth Bearbeitung für die five. Auflage wurde der „Klassiker“ noch einmal besser an die Bedürfnisse des Lesers angepasst, ohne jedoch auf bewährte Inhalte und Elemente zu verzichten. NEU - Neustrukturierung und -zusammenstellung der Themen und Kapitel - Kapitel zu Normalfunktion und gestörter Funktion stehen direkt beieinander, so entfällt mühsames Blättern bei Nachlesen- Multiple-Choice-Fragenkatalog - on-line verfügbar: Qualitativ hochwertige und aktuelle Literaturverzeichnisse BEWÄHRT- Berücksichtigung nationaler und internationaler Leitlinien - Mit Testfragen zur Selbstkontrolle- Zusammenfassungen am Ende jedes Kapitels VERLÄSSLICH- Aktuelles Wissen, leicht verständlich- Praxisrelevante Darstellung aller wichtigen Aspekte des Fachs- Berücksichtigung innovativer Ansätze„Klinische Endokrinologie für Frauenärzte“ - Das Standardwerk mit einer Fülle an täglich anwendbarem Wissen!

Vitamin D

Diet D, a steroid hormone, has mostly been recognized for its results on bone and osteoporosis. the present healing practices extend into such markets as melanoma examine, pediatrics, nephrology, dermatology, immunology, and genetics. This moment variation comprises over a hundred chapters protecting every little thing from chemistry and metabolism to mechanisms of motion, analysis and administration, new analogs, and rising cures.

Extra info for Hormones, Intrauterine Health and Programming

Sample text

Placental 11β-HSD2 Is More than Just a Glucocorticoid Barrier As described above, placental 11β-HSD2 may underpin aspects of developmental programming by allowing excess glucocorticoid passage from the “high” glucocorticoid maternal circulation to the “low” glucocorticoid fetal environment (Edwards et al. 1993), thus impairing fetal growth by direct effects of glucocorticoids on the fetus. Fetal growth is, however, dependent on a complex array of maternal, placental and fetal endocrine signals, and glucocorticoid-mediated fetal growth retardation must also relate, at least in part, to disturbances in placental growth and function.

Ultrasound measures have also revealed altered cardiac function in 11β-HSD2À/À fetuses. Thus, the normal increase in E/A wave ratio [the E wave represents passive filling of the left ventricle (LV) and the A wave represents LV filling due to contraction of the atria] over gestation as the fetal heart becomes more compliant is not apparent in 11β-HSD2À/À hearts (Wyrwoll, unpublished data). Furthermore, the resistance index [RI ¼ systole/(systole + diastole); systole being blood flow during maximal contraction of the heart and diastole being maximal relaxation] in the umbilical artery does not undergo the normal gestational decline as blood flow from the fetus to placenta increases (Wyrwoll, unpublished data).

Endocrinology 147:5568–5574 Hewitt DP, Mark PJ, Waddell BJ (2006b) Placental expression of peroxisome proliferatoractivated receptors in rat pregnancy and the effect of increased glucocorticoid exposure. Biol Reprod 74:23–28 Holmes MC, Abrahamsen CT, French KL, Paterson JM, Mullins JJ, Seckl JR (2006) The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. J Neurosci 26:3840– 3844 Jansson N, Greenwood SL, Johansson BR, Powell TL, Jansson T (2003) Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments.

Download PDF sample

Rated 4.56 of 5 – based on 31 votes