Download Immunotherapy of Renal Cell Carcinoma: Clinical and by W. M. Linehan (auth.), Frans M. J. Debruyne MD, Ph.D., PDF

By W. M. Linehan (auth.), Frans M. J. Debruyne MD, Ph.D., Ronald M. Bukowski MD, J. Edson Pontes MD, Ph.D., Pieter H. M. de Mulder MD, Ph.D. (eds.)

Complex renal cellphone carcinoma is refractory to just about varieties of systemic treatment. hence the decade has noticeable various study teams engaged on immunotherapeutic s trategies opposed to it. Immunotherapy of Renal mobilephone Carcinoma studies the contributions of many of the world's best re- seek teams to 2 overseas meetings at the immu- nobiology of this ailment. 16 chapters divided in expe- rimental and medical reports offer an summary of immuno- treatment in renal telephone carcinoma and a dialogue of recent l. a.- boratory ways to this subject.

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Additional resources for Immunotherapy of Renal Cell Carcinoma: Clinical and Experimental Developments

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R:. 6a,b. g/ml quinidine on in vitro sensitivity to doxorubicin (ADR) in 16 renal cell carcinoma (ReG) samples, which were divided into a group with low levels of MDRI RNA « 20) (a) or a group with high MDRI RNA levels (> 20) (b). , not statistically significant; Q-, absence of quinidine; Q+, presence of quinidine not statistically significant in RCCs with lower MDRI RNA levels, as shown in Fig. 6. These results suggest that P170 contributes to not only vinblastine but also to doxorubicin de novo resistance in RCCs.

HLA expression patterns in BRM-sensitive and -insensitive tumors might give us insight into the mode of action of IFN and 1NF. In a rat renal cell carcinoma model system [23. 39] the antiproliferative activities of recombinant rat 'j'-IFN and recombinant human 1NF were investigated. Rat 'j'-IFN had to be used because of the species specificity of IFN. The tumor was transplanted subcutaneously. the drugs were administered peritumorally. 'j'IFN treatment starting 2 days after tumor implantation resulted in a dose-dependent growth-inhibiting effect.

Tumor necrosis factor alpha (fNF), originally identified as a substance produced by macrophages exposed to endotoxin [8], possesses a number of biological activities, particularly antitumor activity. lNF causes cytostasis or cytolysis of in vitro cell cultures from a variety of animal and human malignant tumors [36] and tumor necrosis in tumor-bearing animals [8]. As shown for other solid tumors, different combinations of a- and ,-IFN and lNF can result in the enhancement of their respective antitumor activities in vitro [9, 15,22] and in vivo [3,33, 37].

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