Download Insulin signaling : from cultured cells to animal models by George Grunberger, Yehiel Zick PDF

By George Grunberger, Yehiel Zick

With contributions from the prime researchers within the box, this quantity brings jointly the most recent stories on insulin motion and sign transduction to supply a state of the art reference for graduate researchers and scholars in diabetes and endocrinology. Insulin Signaling is a accomplished examine of the rules of molecular occasions through insulin at a mobile point, using experimental strategies starting from molecular structures via phenotypic expression in transgenic and knockout types.

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Wertheimer, E. et al. (1992) Mutations in the insulin receptor gene. Endocr. , 13, 566. 2. I. (1992) Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene. Diabetes, 41, 1473. 3. , Kadowaki, H. and Kadowaki, T. (1991) Unusual forms of insulin resistance. Annu. Rev. , 42, 373. 4. M. and Roth, J. (1976) The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man . N. Engl. J. , 294, 739. Insulin signaling 12 5.

79, 1294. 101. , Micossi, P. and Barbetti, F. (1993) Substitution of Leu for Pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance. Hum. Mol. , 2, 1437. 102. , Imamura, T. and Kobayashi, M. (1993) Insulin resistance due to the impaired processing of the mutant insulin receptor [Leu193] . Diabetes, 42 (suppl. 1), 217A (abstract #693). 103. , Yanase, T. and Nawata, H. (1995) Insulin resistance associated with substitution of histidine for arginine 252 in the alpha-subunit of the human insulin receptor: trial of insulin-like growth factor I injection therapy to enhance insulin sensitivity.

1997) and mapping regions of the insulin receptor to this IGF-I receptor structure is now possible, providing additional insight into sites important in insulin binding and in the conformational maturation of the receptor. Interestingly, this fragment does not bind ligand. , 1998). The two large hydrophobic domains (L1, L2, residues 1–157 and 310–470) flanking the cystein rich domain (residues 159–310) are each organized as a single-stranded right-handed β-helix, connected by a rod-shaped cysteine-rich domain.

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