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Extra resources for Kaplan USMLE Step 2: Endocrinology, 2001

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Some of these steroids are reported to have a differential regional distribution and also show age associated changes.

Sanford et al. (1977) have provided evidence which suggests that the human adrenal in castrates produces testosterone which may explain why adrenal ablation can otTer palliation in some patients with prostatic carcinoma. 2. The main androgen secreted by the adrenals is dehydroepiandrosterone (DHEA) and its sulphate conjugate (DHEA-S04). , 1972). 0 mg/24 h (Horton and Tait, 1967). The sulphate conjugate ofDHEA is also secreted by the adrenals. Farnsworth (1973) has presented evidence for DHEA-S04 sulphatase activity in the prostate, which demonstrates the ability of the prostate to convert the sulphated conjugate to its free form.

Using the needle biopsy technique abnormal nodules felt rectally can be sampled and this procedure would thus be expected to give a higher a higher success rate in diagnosing cancer than the more random sampling that occurs with transurethral resection. , 1967). 6 Histopathological pitfalls There are two entities which are often misdiagnosed as carcinoma, squamous metaplasia and basal cell hyperplasia. 13). When the infarct heals the metaplasia may be mistaken for squamous carcinoma and this may account for the relatively high incidence of this tumour in older series (3 % in that reported by Kahler, 1939).

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