Download β-Lactams: Unique Structures of Distinction for Novel by Iwao Ojima, Edison S. Zuniga (auth.), Bimal K. Banik (eds.) PDF

By Iwao Ojima, Edison S. Zuniga (auth.), Bimal K. Banik (eds.)

I. Ojima • E. S. Zuniga • J. D. Seitz: Advances within the Use of Enantiopure β-Lactams for the Synthesis of Biologically energetic Compounds of Medicinal Interests.- I. Fernández • Miguel A. Sierra: β -Lactams from Fischer Carbene Complexes: Scope, boundaries, and response Mechanism.- Bablee Mandal • Basudeb Basu: Synthesis of β-Lactams via Alkyne–Nitrone Cycloadditions.- T. T. Tidwell: instruction of Bis-β-Lactams by means of Ketene–Imine Cycloadditions.- Edward Turos: The Chemistry and Biology of N-Thiolated β-Lactams.- Indrani Banik • Bimal ok. Banik: Synthesis of β-Lactams and Their Chemical Manipulations through Microwave-Induced Reactions.

Show description

Read Online or Download β-Lactams: Unique Structures of Distinction for Novel Molecules PDF

Similar nonfiction_10 books

The Red Cell Membrane: A Model for Solute Transport

"After being often instructed to jot down upon this topic, and as usually declining to do it, from apprehension of my very own lack of ability, i'm at size pressured to soak up the pen, in spite of the fact that unqualified i'll nonetheless consider myself for the duty. " William Withering, M. D. ' i've got but to discover an outline or a quote that larger summanzes my preliminary ambivalence in the direction of embarking on such an recreation as partici­ pating in placing jointly this monograph.

Quantitative methods in budgeting

C. B. TILANUS, EDITOR This booklet attempts to bolster the binds among, at the one hand, the enterprise management and accounting global and, at the different, the operational examine and administration technological know-how global. The readership for which it really is meant is composed ofthe following different types: managers and execs in organizational departments of commercial management, administration technological know-how, computerized facts processing, and so on.

Organization of the Early Vertebrate Embryo

This publication is the manufactured from a NATO complicated learn Institute of an identical identify, held on the Anargyrios and Korgialenios university at the island of Spetsai, Greece, in September 1994. The institute thought of the molecular mechanisms which generate the physique plan in the course of vertebrate embryogenesis. the most issues mentioned incorporated: dedication and imprinting in the course of germ mobilephone differentiation; hierarchies of inductive phone interactions; the molecular functioning of Spemann's organizer and formation of embryonic axes; the extracellular matrix and the cytoskeleton relating to morphogenesis and telephone migration; neurogenesis and patterning of the neuraxis; the legislation of trend formation via Hox genes and different transcription components.

Extra info for β-Lactams: Unique Structures of Distinction for Novel Molecules

Example text

The synthesis of cryptophycin-24 (Arenastatin A) is illustrated in Scheme 76, as a representative total synthesis of this class of compounds [147]. The b-lactam key intermediate 263 was prepared through the coupling of 261, obtained from 259 and 260 in four steps, with N-(p-MeO-Phe)-b-lactam 262. The macrolactonization of 263 was achieved through cyanide-initiated b-lactam ring opening using Bu4NCN and subsequent lactonization. The attempted use of NaH and NaHMDS as base for direct ringopening coupling was unsuccessful, presumably due to the instability of 263 to basic conditions.

However, the conventional ester formation encountered a serious epimerization problem [130] and thus efficient coupling methods needed to be developed. Then, the b-lactam synthon method provided an exceptionally practical solution, featuring the highly efficient ring-opening coupling of N-acyl-b-lactam with a baccatin III derivative [6, 7, 60, 131]. (3S,4R)-1-Benzoyl-3-EEO-4-phenyl-b-lactam 249a (EE ¼ 1-ethoxylethyl) was prepared from (3S,4R)-3-TIPSO-4-phenyl-b-lactam 247 (98% ee) directly obtained through highly efficient chiral ester enolate – N-TMS–imine cyclocondensation (Scheme 72) (vide supra) [6, 60].

Thus, Type 1 alkylation with MeI took place at the C3 position of Advances in the Use of Enantiopure b-Lactams for the Synthesis of. . Ph Ph O O N Ph N O 1 R ii. R2X H N O N (S)-206 (R)-205 Ph Ph O CO2t-Bu O O N i. LiHMDS O i. LiHMDS ii. R1X Ph 39 Ph H i. TFA R2 1 ii. Li/NH3 H2N R R2 R1 CO-NH CO2H (S,S)-207 CO2t-Bu Priority: R1 > R2 N O CO2t-Bu 204 i. LiHMDS ii. R2X Ph Ph O O N Ph N i. LiHMDS O O R2 ii. R2X H N O Ph N O CO2t-Bu (R)-205 H i. TFA R1 HN R2 ii. Li/NH3 2 Ph R1 R2 CO-NH CO2H (S,R)-207 CO2t-Bu (R)-206 Scheme 60 Synthesis of (S,S)-and (S,R)-dipeptides via sequential Type 2 dialkylation Ph Ph O Ph O N O Ph N O 204 i.

Download PDF sample

Rated 4.07 of 5 – based on 9 votes