By W. E. Hull (auth.), PD Dr. med. Sigmund Pomer, William E. Hull PhD (eds.)
The function of this ebook is to supply a few easy information about the basics of magnetic resonance (MR) for all people who are much less accustomed to the process and attracted to MR spectroscopy and its attainable purposes in examine and scientific perform. it is going to stimulate the reader to seem extra heavily on the a variety of themes lined by means of the participants to this quantity: tumor telephone metabolism, kidney functionality, organ viability. ultimately, numerous purposes of high-field spectroscopy and imaging are illustrated. The ebook focusses on confirmed and attainable scientific functions of MR in nephrourology: renal telephone carcinoma, metabolic research of the kidney and pretransplant evaluation of organ viability. The examples are completely mentioned and abundantly illustrated. The reader will take advantage of this booklet via receiving a evaluate of study and medical features of MR simultaneously.
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Extra resources for Magnetic Resonance in Nephrourology: Clinical and Experimental Applications
Magn Reson Med 12:114-136 21. Terrier F, Lazeyras F, Frey BM, Frey FJ (1992) Lactate mapping in ischemic rat kidneys using IH spectroscopic imaging. Invest RadioI27:282-286 22. 7 tesla. J Magn Reson 75:190-192 In Vivo 19F MR Spectroscopy in the Study of Organic Acid Excretion by the Rat Kidney* U. P. Juretschke2 Introduction In traditional clearance studies the urinary excretion of a test substance is measured in relation to its plasma concentration (clearance = UV/P; where V is the urine volume per minute, U the urinary concentration of the test substance, and P the corresponding plasma concentration).
Indeed, it would be of great interest if the clinically important differentiation between acute rejection and cyclosporine nephrotoxicity could rely on precise parameters, for example, the changes in concentration of intrarenal metabolites. This differential diagnosis has direct implications for patient management because it means higher dosage of immunosuppressive agents, on the one hand, or cessation of cyclosporine administration, on the other. Therefore, several authors have expressed the hope that magnetic resonance (MR) spectroscopy can offer measurable and accurate parameters (a) to help establish the etiological diagnosis of posttransplantation renal failure and (b) to evaluate more efficiently the prognosis of a rejection episode so that the decision to continue the treatment or to retransplant can be made on objective grounds.
Our strategy in performing spectroscopy in humans is the "integrated approach" as recommended by Lenkinski , combining imaging and spectroscopy in a single examination. By acquiring MR images and spectra in the same examination, the information gained from each method improves the understanding of the other. Thanks to the images, one can visualize the different tissues cOJ:ltained in the volume being sampled during the spectroscopic experiment, which is crucial for an accurate interpretation of the spectra.