By Attallah Kappas, Chull S. Song (auth.), Hilton A. Salhanick, David M. Kipnis, Raymond L. Vande Wiele (eds.)
The heart for inhabitants learn of the nationwide Institute of kid well-being and Human improvement begun operations in August 1968 and is engaged in learn facing health-related popula tion difficulties. We arrange and aid initiatives for the improve ment of latest contraceptives and within the large box of inhabitants learn within the social sciences o the guts additionally helps numerous initiatives facing the mechanism of motion and scientific results of contraceptives now in use, fairly oral contraceptives and intrauterine units. those reports have been initiated a number of years in the past on the particular course of Congresso We have been happy, for this reason, with the chance to assist manage and help this crucial and well timed convention at the "Metabolic results of Gonadal Hormones and Contraceptive Steroids," the topic of which types a vital part of the Center's learn application. April, 1969 Philip Ao Corfman Director middle for inhabitants examine nationwide Institute of kid well-being and Human improvement v PREFACE development in technology is usually linked to both a "sixth experience" or an inevitable timeliness. either elements, might be, led the individuals of the Endocrinology research portion of the nationwide Institutes of future health to suggest, in 1966, that an accelerated view of the results of gonadal hormones, typically, and the contra ceptive steroids, specifically. was once wanted. There have been abundant reviews of the scientific symptomatology, contraceptive efficacy, and results at the reproductive procedure, yet there has been a dearth of knowledge on their a number of systemic'metabolic effects.
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Extra info for Metabolic Effects of Gonadal Hormones and Contraceptive Steroids
P. 309. 2. N. : Impairment of hepatic excretion of sulfobromophthalein (BSP) by natural estrogens. Trans. Assoc. Am. Phys. 12:248-258 (1964). 3. N. : Estrogen pharmacology. I. The influence of estradiol and estriol on the hepatic disposal of sulfobromophthalein (BSP) in man. J. Clin. Invest. 43:19051914 (1964). 4. L. : Estrogen pharmacology. III. Effect of estradiol on plasma disappearance rate of sulfobromophthalein in man. Arch. Intern. Med. 117:373-376 (1966). 5. N. : Estrogen pharmacology. IV.
Involvement of the bile salt excretory mechanism) would occur. In recurrent cho1estasis with or without pregnancy, an initial effect of oral contraceptives on BSP excretion may occur, but this has not been specifically studied. In the latter disorders, a non-dose related response to oral contraceptives affects the bile salt excretory mechanism producing bile secretory failure and cho1estasis. In patients with post-necrotic cirrhosis, oral contraceptives result in bile secretory failure probably because hepatic excretory function is greatly reduced in this disease.
A wide variety of other neutral and acidic steroids do not induce BSP retention in this system. Estrogens, while inducing an alteration in liver function, do not produce significant morphological changes demonstrable by light or electron microscopy. In contrast, 17-methy1 testosterone (XXX), which did not impair BSP excretion in the amounts used, did produce marked canalicular dilatation in the livers of test animals. Forker (14) has also reported recently that rats treated with estrone have impairment of BSP excretion without morphological cho1estasis.