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By Claude Kordon, Iain Clarke

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Life Sci 1985; 37: 617–623. 61 Bauer-Dantoin AC, Urban J, Levine J: Neuropeptide Y gene expression in the arcuate nucleus is increased during preovulatory luteinizing hormone surges. Endocrinology 1992;131:2953–2958. Neuropeptide Signaling in Metabolism and Reproduction 62 Sahu A, Crowley W, Kalra S: Hypothalamic neuropeptide-Y gene expression increases before the onset of the ovarian steroid-induced luteinizing hormone surge. Endocrinology 1994; 134:1018–1022. 63 Pierroz D, Gruaz N, D’Alieves V, Aubert ML: Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat.

And third, these neuropeptides have either direct or indirect effects on feeding and metabolism, as well as on the secretion of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH). As the target for the action of metabolic hormones and sex steroids, these neuropeptides serve as molecular motifs integrating the control of metabolism and reproduction. Copyright © 2007 S. Karger AG, Basel © 2007 S. com/nen Energetics and Reproduction Species viability is predicated on reproductive success.

Endocrinology 1976; 98: 1359–1364. 13 Barash I, Cheung CC, Weigle DS, Ren H, Kabigting E, Kuijper J, Clifton D, Steiner RA: Leptin is a metabolic signal to the reproductive system. Endocrinology 1996; 137: 3144– 3147. 14 Chehab F, Lim M, Lu R: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996;12:318–320. 15 Mounzih K, Lu R, Chehab FF: Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 1997;138:1190– 1193.

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