Download Neuroendocrinology of Leptin by Ehud Ur PDF

By Ehud Ur

The invention of the adipostatic hormone leptin has reworked our knowing of the neurobiology of urge for food keep an eye on and has helped to set up the organic foundation of weight problems. This quantity units out to attract jointly key good points of the critical results of leptin. Contributions from prime specialists within the box contain reports of leptin's activities on hypothalamic peptides, the function of leptin in fasting, its results on reproductive functionality, and facts helping endogenous mind creation of the peptide.

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Extra resources for Neuroendocrinology of Leptin

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Broadwell RD, Brightman MW: Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 1976;166:257–283. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 1996;17:305–311. Erickson JC, Hollopeter G, Palmiter RD: Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996;274:1704–1707. Elmquist 38 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 Erickson JC, Clegg KE, Palmiter RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y (see comments).

Since leptin deficiency and insensitivity to leptin are associated with endocrine abnormalities similar to fasting, we hypothesized that the fall in leptin is an important mediator of the adaptation to fasting [16]. Studies from our laboratory and others support such a role of leptin [16–18].

For example, growth hormone falls with fasting in rodents but is elevated in the early phase of fasting in humans [1, 9]. In contrast, levels of insulin-like growth factor-I are suppressed during fasting [10]. These diverse changes in hormone levels are likely to promote survival by stimulating food ingestion and conserving energy through reduction of thyroid thermogenesis, and decreased growth and reproduction. The signals which mediate the interaction between energy stores and diverse hormonal changes during fasting are largely unknown.

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