By Javaid Kassim, Paul Sponseller MD MBA, Jay R. Shapiro MD
Osteogenesis Imperfecta is the 1st translational reference execs can flip to for a resource of accomplished details in this ailment. even supposing numerous experiences of the sphere were released in quite a few journals, there isn't any different unmarried resource for a compendium of present details. Separate chapters speak about all the numerous medical positive factors of OI. moral matters concerning OI are mentioned, as is the significance of nutrients in handling the OI baby and the OI grownup. The function of actual medication and rehabilitation for OI sufferers is usually provided, in addition to the present prestige of OI scientific remedy and the customers for genetic engineering sooner or later. The textual content additionally presents the orthopedic doctor with a sophisticated dialogue of surgical innovations acceptable to OI.
- Incorporates chapters and knowledge at the moral concerns regarding osteogenesis imperfecta (OI) as will the significance of foodstuff in dealing with the OI baby and the OI adult
- Offers new insights into the underlying mechanisms of collagen biochemistry as with regards to OI in addition to a presentation of intracellular collagen processing and the improved function of protein chaperones in OI
- Discusses the function of actual medication and rehabilitation for OI sufferers and the present prestige of OI scientific therapy in addition to customers for genetic engineering within the future
- Provides a different evaluate for the orthopedic doctor with a sophisticated dialogue of surgical ideas appropriate to OI
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Additional info for Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease
6,7,77–80 The relative prevalence of mutations in different genes might therefore be reflected in a different prevalence of various types of OI in separate human populations. 8 In 1975, such was the state of knowledge of matrix biology including collagen (type I) biochemistry that very little light was shed on this subject of genetic heterogeneity, but the knowledge base was rapidly changing. After 30 years of intense study of collagen (1952–1982), which in retrospect was collagen type I, and recognition that there were other fibrillar collagens in cartilage and blood vessels distinguishable at the biochemical, biophysical and ultrastructural level,9,10 the conditions were present by 1975 for a major leap forward in discovery of the molecular pathology of OI.
Here, the editorial objective was to include as many OI-related topics as space permits, because at this time of near scientific explosion, drawing a boundary line might miss what will be important in the near future. The editors express their appreciation to each of the authors who have contributed their scientific experience and insight to the production of this book. The editors also express sincere appreciation to the staff of Elsevier, in particular, Ms. Mara Connors and Megan Wickline, who have provided counsel and guidance at each stage of production.
Clinical and Genetic Classification of Osteogenesis Imperfecta and Epidemiology Introduction Clinical and Genetic Classifications of OI Epidemiology of OI References Chapter 3. The Osteogenesis Imperfecta Community and Scientific Research: A Valuable Partnership OI Foundation History OI Research is Complicated The Role of the OI Foundation in Research A Model that Works But Wait, There’s More In Conclusion II: Bone Biology, Structure and Biochemistry Chapter 4. Mineralized Tissue: Histology, Biology and Biochemistry Introduction Methodology Normal and OI Mineralization Processes Conclusions Acknowledgments References Chapter 5.