By Nanette F. Santoro, Amber R. Cooper
Presenting the most up-tp-date and proper info at the analysis and administration of fundamental ovarian insufficiency, sometimes called untimely ovarian failure (POI/POF), this ebook provides both very important voices. the 1st is the clinical, evidence-based voice discussing the newest info on POI/POF in a concise and logical model: etiologies, indicators, genetics, mechanisms, linked stipulations, in addition to mental and way of life issues. the second one voice offers the first-person tales of affected girls, who're frequently confronted with a prognosis of irreversible infertility at a truly younger age and who someway learn how to reside with nice uncertainty approximately their skill to create a relatives – a center id factor for lots of ladies. it's hence no longer easily a scientific, case-based presentation, yet a extra collaborative attempt among clinicians who're well-versed within the box and girls who've POI/POF. Primary Ovarian Insufficiency: A scientific advisor to Early Menopause will accordingly be a superb useful but own reference for OB/GYNs, reproductive drugs experts, and any clinician, nurse or health and wellbeing care employee treating ladies dwelling with POI/POF.
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Extra info for Primary Ovarian Insufficiency: A Clinical Guide to Early Menopause
Although the median lethal dose (LD50) of primordial follicles has been reported to be between 2 and 6–18 Gray (Gy) [160, 161], it is estimated that as little as 2 Gy is able to cause loss of the half of human follicles . 3 Gy [162, 163]. 5 years developed POI by the age of 23 . Patients who receive a stem cell transplant with total body irradiation are at the greatest risk of developing POI. Virtually 100 % of patients who undergo a marrow transplant with total body irradiation after age 10 will develop acute ovarian failure, whereas 50 % of girls who received total body irradiation before the age of 10 will suffer from acute loss of ovarian function .
7) Effects of 2- or 4- week repeated dose studies and fertility study of cyclophosphamide in female rats. J Toxicol Sci. 2009;34 Suppl 1:SP83–9. 179. Byrne J, et al. Early menopause in long-term survivors of cancer during adolescence. Am J Obstet Gynecol. 1992;166(3):788–93. 180. Yuan H, et al. Comparison of the effect of laparoscopic supracervical and total hysterectomy for uterine fibroids on ovarian reserve by assessing serum anti-Mullerian hormone levels: a prospective cohort study. J Minim Invasive Gynecol.
Cramer DW, Xu H, Harlow BL. Family history as a predictor of early menopause. Fertil Steril. 1995;64(4):740–5. 16. Vegetti W, et al. Inheritance in idiopathic premature ovarian failure: analysis of 71 cases. Hum Reprod. 1998;13(7):1796–800. 17. van Asselt KM, et al. Heritability of menopausal age in mothers and daughters. Fertil Steril. 2004;82(5):1348–51. 18. Janse F, et al. Similar phenotype characteristics comparing familial and sporadic premature ovarian failure. Menopause. 2010;17(4):758–65.