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Given their economic importance and public concerns about battery-raised chickens, it is somewhat surprising that relatively little has been published on the effects of stressors on immunity in domestic fowl. , 1994). For example, social isolation as a stressor in young domestic fowl led to an increase in the number of leukocytes in the blood, but not in the spleen. , 1994). , 2002). In a study examining free-living Adelie penguins, repeated handling had no effect on heterophil/lymphocyte ratios, but nesting status did.

Aluru et al. (2004) found that in the Artic char, PCB disrupts the HPI axis. The immunological consequences of the associated downregulation of brain glucocorticoids warrants exploration in normal and stressed fish. Similar considerations apply to other taxa, including mammals (Lawrence and Kim, 2000). These 7/11/2006 4:38:31 PM 27 Prologue speculations certainly provide an ecologically valid rationale for better understanding the mechanisms underlying neural-immune system cross-talk in endothermic as well as ectothermic species.

El-Far, A. , Mashaly, M. , and Kamar, G. A. (1994). Bursectomy and in vitro response of adrenal gland to adrenocorticotropic hormone and testis to human chorionic gonadotropin in immature male chickens. , 73, 113–117. Ellis, A. E. (1981). Stress and the modulation of defence mechanisms in fish. In A. D. ), Stress in fish (pp. 147–169). London: Academic Press. Ellsaesser, C. , and Clem, L. W. (1987). Cortisol-induced hematologic and immunologic changes in channel catfish (Ictalurus punctatus). Comp.

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