Download The Genetics of Type 2 Diabetes and Related Traits: Biology, by Jose C. Florez PDF

By Jose C. Florez

This e-book provides the cutting-edge of kind 2 diabetes genetics, from the method of genetic discovery to its interpretation and scientific software, and illustrates a version for different complicated human phenotypes.The first part explores genome-wide organization reviews, the extension of this technique to much less obtainable phenotypes and the coming of next-generation sequencing. another part is going past genetics to demonstrate how different information resources will help interpret genetic facts, akin to leveraging inhabitants range, the correlation of genetic institutions with physiological measurements, gene expression modulation, environmental components and our microbial commensals. The 3rd part describes advances in elucidating the advanced direction from organization to operate utilizing in-depth sequencing and sensible reports of the mobile and molecular results of genes within the loci pointed out by way of genetics. the ultimate part hyperlinks our present knowing with clinically suitable questions, resembling prediction, interactions with medicinal drugs or foodstuff, and illness prevention, and paints a pragmatic yet hopeful imaginative and prescient of the long run.

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Extra info for The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation

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2014), Nat Genet Morris et al. (2012), Nat Genet Steinthorsdottir et al. (2014), Nat Genet Morris et al. (2012), Nat Genet Morris et al. (2012), Nat Genet Morris et al. (2012), Nat Genet Morris et al. (2012), Nat Genet DIAGRAM Consortium et al. (2014), Nat Genet Saxena et al. (2013), Diabetesc Steinthorsdottir et al. (2014), Nat Genet Morris et al. (2012), Nat Genet 30 R. Sladek and I. 35 2012 2012 2007 2014 2014 2014 2010 2012 2007 2010 2011 2010 2011 2010 2013 (continued) Li et al. (2013), Diabetesc Morris et al.

Sladek and I. Prokopenko (Saxena et al. 78) with BMI-associated rs2287019 (Speliotes et al. 2010). Genome-wide meta-analysis of HbA1c, including study in 46,368 in nondiabetic individuals by the MAGIC investigators, identified 10 genetic loci, of which MTNR1B and GCK also increase T2D risk, suggesting that their effect on hyperglycemia (as measured by FG) extends an effect on average glycemia over a 2- to 3-month period (as detected through HbA1c) and is related to T2D pathogenesis, while ANK1 maps close to T2D risk variant (Soranzo et al.

For loci with sex differentiation, the effect size for the sex with larger effect is presented. X-axis lists loci names, labeled by the gene names within region. Yaxis shows odds ratio for T2D observed at a given locus. Loci are split by the year of discovery and are ordered from top to bottom by the decreasing OR on T2D risk within each year. 23 2009 2011 2010 2012 2013 2010 2008 2010 2010 2008 2014 Year first association report 2013 (continued) Locus lead SNP, effect size, and allele frequency reference Albrechtsen et al.

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