By Jerome Strauss, Robert Barbieri
For greater than 25 years, Reproductive Endocrinology has stood because the optimum reference at the capabilities and problems of human copy. Now a brand new variation returns with all of its conventional strengths-coupled with the very most modern details! up-to-date all through, the fifth version good points the paintings of recent editors Jerry Strauss, MD, and Robert Barbieri, MD-leaders within the box of reproductive endocrinology. jointly, with a crew of the world over well-known specialists, they discover what readers want to know to effectively diagnose and deal with nearly each reproductive endocrine disorder.• comprises thirteen absolutely new chapters that hide today's preferred topics.
• good points 24 chapters with new themes or new authors that discover subject matters shaping today's practice.
• Covers the entire spectrum of reproductive pathophysiology and problems, from being pregnant and beginning to reproductive aging
• bargains a brand new part on reproductive applied sciences that emphasizes the developments in reproductive expertise, together with in vitro fertilization * intracytoplasmic sperm injection * genetic suggestions which are utilized to gametes and embryos * new techniques to utilizing recombinant gonadotropins to urge ovulation * and endocrinology of getting older in adult females and males.
• Discusses sizzling themes reminiscent of the therapy of andrology, gamete biology correct to assisted reproductive expertise, the endocrinology of getting older, and hormones and cancer.
• encompasses a reorganized and streamlined layout for better ease of use
Read Online or Download Yen and Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management (6th Edition) PDF
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Additional resources for Yen and Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management (6th Edition)
Indeed, the phenomenon of seasonal breeding—which is characteristic of most nonequatorial mammals—reflects the effect of seasonal food availability on reproductive success. , fat) to address the caloric demands of mating (consider the rutting elk), pregnancy, and lactation. The energy burden of reproduction rests more heavily on females than on males, and thus the effect of caloric restriction (and limited fat reserves) is greater in females. , glucose, amino acids, fatty acids). One of the most astonishing features of the effect of diet on reproduction is how rapidly the body responds— often within just days (Fig.
Amino acid sequences of human α gonadotropin subunit� (α-GSU), �� luteinizing hormone (LH)β, chorionic gonadotropin (CG)β, and follicle-stimulating hormone (FSH)β. html), and the β subunits are aligned to maximize homology. Identical, highly conserved, and semiconserved residues among the three β subunits are highlighted by the blue, green, and yellow boxes, respectively. All cysteines participate in disulfide bond formation in the native proteins. hCG, human chorionic gonadotropin; hFSH, human follicle-stimulating hormone; hLH, human luteinizing hormone.
In both hCG and hFSH, the two subunits are associated in a head-to-tail arrangement. Although there are no structures available for LH and TSH, the similarities of the hCG and FSH structures engender confidence that the overall conformations of LH and TSH will be closely related to the known structures. There are subtle, but perhaps important differences in the common α-GSU in hCG and hFSH. Larger differences were found between hCGβ and hFSHβ, particularly in the C-terminal region of the seatbelt, an important region of the β subunit that wraps around a portion of α-GSU.