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Extra info for Radioactive Isotopes in Clinical Medicine and Research: Proceedings of the 22nd International Badgastein Symposium
Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 1987; 235: 1495-1498. 5. Flier IS, Mueckler MM, Usher P, Lodish H. Elevated levels of glucose transport and trasporter messenger RNA are induced by ras or src oncogenes. Science 1987; 235: 1492-1495. 6. Yarnarnoto T, Seino Y, Fukumoto H et al. Overexpression of facilitated glucose transporter genes in human cancer. Biochem Biophys Res Commun 1990; 170: 223-230. 7. Nishioka T, Oda Y, Seino Y et al.
5, which is specific for yttrium-DOTA, but nonspecific for the tumor. Tumor uptake was by passive diffusion of mAb through leaky neovasculature in the tumor. 5 (0 h), 2) polyvalent hapten-protein conjugate chase (20 h), 3) 88Y-Iabeled monovalent DOTA, orbivalent Janus-DOTA haptens (21 h) and organ & rumor bioassay (24 h). RESUL TS AND DISCUSSION With therapeutic radionuclides like 90y, the long biological half-life of directly labeled mAb imposes a high radiation burden on sensitive normal tissues from the large amount of reuined radioactivity.
J Nucl Med 1988; 29: 226-234. 2. Reardon DT, Meares CF, Goodwin DA, et al: Antibodies against meta! chelates. Nature 1985; 316:265-268. 3. Le Doussal I-M, Martin M, Gautherot E, Delaage M, and Barbet 1. In vitro and in-vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate. J Nucl Med 1989; 30:1358-1366. 4. M. Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma.