Download Radioactive Isotopes in Clinical Medicine and Research: by P. Rigo, P. Paulus, T. Bury, G. Jerusalem, R. Hustinx, T. PDF

By P. Rigo, P. Paulus, T. Bury, G. Jerusalem, R. Hustinx, T. Benoit, M. P. Larock (auth.), Professor Dr. H. Bergmann, Prim. Dozent Dr. A. Kroiss, Professor Dr. H. Sinzinger (eds.)

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Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 1987; 235: 1495-1498. 5. Flier IS, Mueckler MM, Usher P, Lodish H. Elevated levels of glucose transport and trasporter messenger RNA are induced by ras or src oncogenes. Science 1987; 235: 1492-1495. 6. Yarnarnoto T, Seino Y, Fukumoto H et al. Overexpression of facilitated glucose transporter genes in human cancer. Biochem Biophys Res Commun 1990; 170: 223-230. 7. Nishioka T, Oda Y, Seino Y et al.

5, which is specific for yttrium-DOTA, but nonspecific for the tumor. Tumor uptake was by passive diffusion of mAb through leaky neovasculature in the tumor. 5 (0 h), 2) polyvalent hapten-protein conjugate chase (20 h), 3) 88Y-Iabeled monovalent DOTA, orbivalent Janus-DOTA haptens (21 h) and organ & rumor bioassay (24 h). RESUL TS AND DISCUSSION With therapeutic radionuclides like 90y, the long biological half-life of directly labeled mAb imposes a high radiation burden on sensitive normal tissues from the large amount of reuined radioactivity.

J Nucl Med 1988; 29: 226-234. 2. Reardon DT, Meares CF, Goodwin DA, et al: Antibodies against meta! chelates. Nature 1985; 316:265-268. 3. Le Doussal I-M, Martin M, Gautherot E, Delaage M, and Barbet 1. In vitro and in-vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate. J Nucl Med 1989; 30:1358-1366. 4. M. Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma.

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